Renal Function Preservation with Pioglitazone or with Basal Insulin As an Add-on Therapy for Patients with Type 2 Diabetes Mellitus.

Clinical outcome may differ owing to the distinct pharmacological characteristics of insulin sensitizers and insulin. This study was performed to compare the metabolic and renal function changes with add-on pioglitazone treatment versus basal insulin in patients with type 2 diabetes mellitus (DM) in whom sulfonylurea and metformin regimens failed.