Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation.

Sai Vikram Vemula, Jill W Maxwell,Alexey Nefedov,Bang-Lin Wan, Justin Steve,William Newhard,Rosa I Sanchez,David Tellers,Richard J Barnard,Wade Blair,Daria Hazuda,Andrea L Webber,Bonnie J Howell

Antiviral Research（2017）

引用 15|浏览20

暂无评分

摘要

•RNASeq of PKC agonists in human CD4 T cells reveals altered signalling pathways and time-dependent changes in gene expression.•Several biomarkers of PKC agonisms were identified and validated in human CD4+ T cells and in in vivo rat studies.•Egr family members have a role in PKC mediated latent HIV-1 reactivation.

查看译文

关键词

HIV latency,Protein kinase C agonists,Biomarkers

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要