Simultaneous determination of amantadine, rimantadine, and memantine in processed products, chicken tissues, and eggs by liquid chromatography with tandem mass spectrometry.

•The new validated LC–MS/MS method allows for simultaneous determination of amantadine, rimantadine, and memantine in four processed products, three chicken tissues, and eggs.•On a modern Kinetex® XB-C18 core–shell technology column using a mobile phase of acetonitrile and 0.1% formic acid in 10mmol/L ammonium formate solution, three adamantane drugs could be completely separated.•This procedure had a good efficiency by modifying the process of QuEChERS extraction and using a two-step clean-up procedure: liquid-liquid distribution and Oasis® MCX cartridge purification.•The external solvent calibration curves were able to accurately quantify three analytes because matrix effects were made negligible by removing matrices in the samples.