Discovering alkylamide derivatives of bexarotene as new therapeutic agents against triple-negative breast cancer.

Luxi Chen,Chao Long,Jennifer Nguyen,Dhiraj Kumar,Jiyong Lee

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

•The derivatives exert cytotoxicity in TNBC cells.•Alkylamide derivatives of bexarotene induce apoptosis in TNBC cell lines.•The derivatives inhibit proliferation and cell migration of TNBC cells.•The derivatives suppress CSC and EMT properties of TNBC cell lines.

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关键词

Triple-negative breast cancer,Apoptosis,Cancer stem cell,Epithelial-mesenchymal transition,Anti-cancer therapeutics

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