Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers.

Amyloid-beta (A beta) oligomers are causative agents triggering AD pathogenesis, but their elimination remains challenging. We herein reported a natural cyclopeptide tyrocidine A prevents and reverses amyloidogenesis without A beta oligomer accumulation by stabilizing the monomeric, but not the oligomeric state of A beta peptides.