A water-soluble pillar[5]arene as a new carrier for an old drug

Lucia Barbera,Domenico Franco,Laura M De Plano,Giuseppe Gattuso,Salvatore P P Guglielmino,Germana Lentini,Nadia Manganaro,Nino Marino,Sebastiano Pappalardo,Melchiorre F Parisi,Fausto Puntoriero,Ilenia Pisagatti,Anna Notti

Organic & Biomolecular Chemistry（2017）

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摘要

The remarkable affinity of deca-carboxylatopillar[5] arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.

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