Simultaneous Measurement of Macro- and Microvascular Blood Flow and Oxygen Saturation for Quantification of Muscle Oxygen Consumption
Magnetic resonance in medicine(2017)
摘要
PurposeTo investigate the relationship between blood flow and oxygen consumption in skeletal muscle, a technique called Velocity and Perfusion, Intravascular Venous Oxygen saturation and T2*` (vPIVOT) is presented. vPIVOT allows the quantification of feeding artery blood flow velocity, perfusion, draining vein oxygen saturation, and muscle T2*', all at 4-s temporal resolution. Together, the measurement of blood flow and oxygen extraction can yield muscle oxygen consumption (VO2) via the Fick principle. MethodsIn five subjects, vPIVOT-derived results were compared with those obtained from stand-alone sequences during separate ischemia-reperfusion paradigms to investigate the presence of measurement bias. Subsequently, in 10 subjects, vPIVOT was applied to assess muscle hemodynamics and VO2 following a bout of dynamic plantar flexion contractions. ResultsFrom the ischemia-reperfusion paradigm, no significant differences were observed between data from vPIVOT and comparison sequences. After exercise, the macrovascular flow response reached a maximum 83 s after relaxation; however, perfusion in the gastrocnemius muscle continued to rise for 101 +/- 53 s. Peak VO2 calculated based on mass-normalized arterial blood flow or perfusion was 15.2 +/- 6.7mL O-2/min/100g or 6.0 +/- 1.9mL O-2/min/100g, respectively. ConclusionsvPIVOT is a new method to measure blood flow and oxygen saturation, and therefore to quantify muscle oxygen consumption. Magn Reson Med 79:846-855, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.
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关键词
muscle,oxygen consumption,exercise,ischemia,perfusion
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