Catalytic asymmetric formal total syntheses of (+)- and (-)-cycloclavine.

CHEMICAL COMMUNICATIONS(2018)

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摘要
We report an expeditious catalytic asymmetric approach to clavine alkaloids via a key Heck cyclization. This reaction sets the formation of vicinal stereocenters with excellent diastereoselectivity. Utilizing the aforementioned strategy, the formal total synthesis of cycloclavine (1) has been achieved via another key late-stage esteraminolysis of 6.
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