Domino Carbopalladation/C–H Activation as a Quick Access to Polycyclic Frameworks
Organic Letters(2018)
摘要
A new type of domino reaction for synthesis of heterocycles fusing the important bioactive cores, such as oxindole, indoline, and isoquinoline, is presented. Upon exposure to the very common palladium catalyst, the conceptually designed N-alkenyl iodobiaryls undergo a sequential carbopalladation/C–H activation to build polycyclic frameworks. These novel unique frameworks may provide structure sources in fragment-based drug discovery.
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关键词
polycyclic frameworks
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