Protocolized warfarin reversal with 4-factor prothrombin complex concentrate versus 3-factor prothrombin complex concentrate with recombinant factor VIIa.

Cassie A Barton, Marissa Hom,Nathan B Johnson,Jon Case,Ran Ran,Martin Schreiber

The American Journal of Surgery（2018）

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摘要

•Three factor PCC combined with rFVIIa and four factor PCC were both efficacious at reducing the INR in patients needing emergent warfarin reversal.•Three factor PCC with rFVIIa was associated with a significant thromboembolic risk.•Three factor PCC and rFVIIa in combination should be avoided as a reversal strategy due to the high thromboembolic risk.

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关键词

Warfarin,Prothrombin complex concentrate,Reversal,Recombinant factor VIIa,Anticoagulation

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