Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia
NATURE(2018)
摘要
Mutations in the nucleotidase-encoding gene NT5C2 drive chemotherapy resistance in relapsed acute lymphoid leukaemia but the mutations also lead to a loss-of-fitness phenotype and to collateral drug sensitivity, which could be exploited for therapy.
更多查看译文
关键词
Acute lymphocytic leukaemia,Cancer metabolism,Cancer models,Science,Humanities and Social Sciences,multidisciplinary
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要