Multivariate calibration of energy-dispersive X-ray diffraction data for predicting the composition of pharmaceutical tablets in packaging.

•Non-destructive screening of unpackaged and packaged tablet formulations.•High accuracy of quantification using multivariate calibration methods.•Data pre-treatment prior to modelling and prediction not required.•Improved prediction accuracy compared to angular dispersive X-ray diffraction and comparable to Raman spectroscopy.