HLA class I antigen processing machinery (APM) component expression and PD-1:PD-L1 pathway activation in HIV-infected head and neck cancers.

Sara I Pai,J Jack Lee,Thomas E Carey,William H Westra,Soldano Ferrone,Charles Moore,Marina B Mosunjac,Dong M Shin,Robert L Ferris

Oral Oncology（2018）

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摘要

•HIV status has precluded patient treatment with immune checkpoint blockade.•HLA Class I APM components and the PD-1:PD-L1 axis are assessed in HIV+ patients.•HIV status should be reconsidered as an exclusionary criterion for immunotherapy.

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关键词

Human immunodeficiency virus,Human Papillomavirus,Head and neck cancer,PD-1,PD-L1,Immune checkpoint blockade,Antigen processing machinery

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