Targeting cell surface HIV-1 Env protein to suppress infectious virus formation.

Arangassery Rosemary Bastian,Charles G Ang,Kantharaju Kamanna,Farida Shaheen, Yu-Hung Huang,Karyn McFadden,Caitlin Duffy,Lauren D Bailey,Ramalingam Venkat Kalyana Sundaram,Irwin Chaiken

Virus Research（2017）

引用 6|浏览14

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摘要

•Both peptide triazole thiols and their multivalent conjugates on AuNPs can inactivate HIV-1 Env.•HIV-1 Env protein inactivators can target Env gp120 proteins on virus-producing cells.•Targeting virus-producing cells suppresses new infectious virus formation.•Metastability of HIV-1 Env is a strategic vulnerability of both viruses and cells.•Env targeting by multivalent inactivators has potential for infected cell killing.

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关键词

HIV-1,Gold nanoparticles,Infected cell inactivation,Multivalency,Peptide triazoles

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