Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome.

Leonard Izzard,Daniel Dlugolenski,Yingju Xia,Meagan McMahon,Deborah Middleton,Ralph A Tripp,John Stambas

Virus Research（2017）

引用 17|浏览28

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摘要

•Incorporation of miR-155 into the influenza A virus genome highlights the potential of this technology to create self-adjuvanting live vaccines.•miRNA-155 expression enhanced influenza-specific CD8+ T cell responses.•miRNA-155 expression enhanced influenza-specific antibody responses.

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关键词

RNAi,miR-155,Influenza A,T cell,B cell,Vaccine

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