Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: Reduced dopaminergic modulation and immediate gene expression in limbic circuits.

•Cannabidiol infusion into the prefrontal cortex impaires fear memory consolidation when applied 5h after conditioning but not when applied immediately after training.•Cannabidiol decreases dopamine release in the prefrontal cortex following memory retrieval 5days after training.•Post-training infusion of cannabidiol reduces c-fos and zif-268 gene expression in cortico-limbic circuits following memory retrieval.