The deposition of anti-DNA IgG contributes to the development of cutaneous lupus erythematosus

Yingying Dong,Yi Zhang,Linlin Xia,Ping Wang,Jingyun Chen,Meifeng Xu,Xingyin Liu,Yumin Xia

Immunology Letters（2017）

引用 13|浏览15

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摘要

•Anti-DNA IgG exists in skin lesion of lupus erythematosus and recognizes novel antigens.•Binding of anti-dsDNA IgG to keratinocytes induces macrophage chemoattraction.•Anti-dsDNA IgG amplifies effect of TWEAK/Fn14 activation on keratinocytes.•Anti-dsDNA IgG regulates SOCS1 signals in keratinocytes.

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关键词

CCL,CLE,ELISA,Fn14,JAK,IP-10,MCP-1,qRT-PCR,RANTES,SOCS1,SPR,STAT,TNF,TWEAK,UVB

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