A regulatory circuitry between miR-193a/miR-600 and WT1 enhances leukemogenesis in acute myeloid leukemia.

•Expression of miR-193a and miR-600 is decreased in patients with acute myeloid leukemia (AML).•MiR-193a and miR-600 synergistically reduce WT1 expression in AML cells.•WT1 inhibits miR-600 expression by binding the putative pre-miR-600 promoter.•MiR-193a and miR-600 have anti-leukemia activity.