Dcr3 Gene Polymorphisms Are Associated With Sporadic Breast Infiltrating Ductal Carcinoma In Northeast Chinese Women

Decoy Receptor 3 (DcR3), also called TNFRSF6 beta, is a member of the tumor necrosis factor receptor superfamily and is a soluble receptor for FasL. DcR3 is overexpressed in cancers and contributes to tumorigenesis through immune suppression and promotion of angiogenesis. We found that DcR3 is overexpressed in breast infiltrating ductal carcinoma (IDC) cells as compared with normal controls. We also conducted a case-control study analyzing associations of DcR3 polymorphisms with breast IDC risk. Subjects included 531 females with breast IDC and 592 age-matched healthy controls. Four DcR3 single nucleotide polymorphism loci with minor frequencies of more than 5% (rs3208008, rs41309931, rs2297441 and rs1291207) were genotyped using polymerase chain reaction restriction fragment length polymorphism and sequencing. Our results revealed significant differences in rs41309931genotypes and alleles (P < 0.01). Based on Haploview software analysis, the haplotype block A(rs3208008) G(rs41309931) G(rs2297441) A(rs1291207) exhibited the highest frequency, but, haplotype blocks A(rs3208008) T-rs41309931 G(rs2297441) A(rs1291207) and C-rs3208008 G(rs41309931) G(rs2297441) A(rs1291207) were associated with breast IDC risk. This study also detected associations between DcR3 gene polymorphisms and the clinicopathological features of breast IDC, including lymph node metastasis and C-erbB2, P53, estrogen receptor and progesterone receptor status. These data indicate that DcR3 gene polymorphisms are associated with sporadic breast IDC risk in Northeast Chinese females.