Defective Bone Repair in C57Bl6 Mice with Acute Systemic Inflammation
Clinical orthopaedics and related research(2017)
Abstract
Bone repair is initiated with a local inflammatory response to injury. The presence of systemic inflammation impairs bone healing and often leads to malunion, although the underlying mechanisms remain poorly defined. Our research objective was to use a mouse model of cortical bone repair to determine the effect of systemic inflammation on cells in the bone healing microenvironment.
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Key words
Bone Healing,Systemic Inflammation,Bone Repair,Trabecular Separation,Impaired Bone Healing
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