Microthecaline A, A Quinoline Serrulatane Alkaloid From The Roots Of The Australian Desert Plant Eremophila Microtheca

Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 mu M. Microthecaline A represents the first quinoline-serrulatane alkaloid to be isolated from Nature.