Racemic Meroterpenoids from Ganoderma Cochlear
FITOTERAPIA(2018)
Abstract
Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pairs of racemates, ( +/- )-cochlearins A-E, G (1-5, 7), and three new analogues, cochlearins F, H and I (6, 8, 9). Their structures were elucidated by extensive 1D, 2D NMR spectroscopic data and MS analyses. The stereostructures of ( +/- )-cochlearins A and B (1 and 2) were assigned using electronic circular dichroism (ECD) calculations. All of the isolates showed comparable antioxidant activities with IC50 values of 3.1 +/- 0.1-5.3 +/- 0.1 mu M, compared to the positive control (trolox, IC50: 3.3 +/- 0.1 mu M). ( +/- )-Cochlearin D (4) and (+)-4 exhibited weak inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1).
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Key words
Ganoderma cochlear,Ganodermataceae,Aromatic meroterpenoids,Liver fibrosis,Antioxidant activities
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