Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice.

Pernille Wismann,Søren L Pedersen,Gitte Hansen,Karin Mannerstedt,Philip J Pedersen,Palle B Jeppesen,Niels Vrang,Keld Fosgerau,Jacob Jelsing

Physiology & Behavior（2018）

引用 32|浏览16

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摘要

•GUB09-123 is a novel GLP-1/GLP-2 co-agonist.•GUB09-123 improves glucose homeostasis and increases gut volume.•GUB09-145 is a pharmacokinetically improved lipidated GLP-1/GLP-2 co-agonist.•GUB09-145 reduces body weight while maintaining intestinotrophic effects.

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关键词

GLP-1,GLP-2,Co-agonist,Diabetes,Obesity,Short bowel syndrome,Intestinal growth,Glucose homeostasis

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