Vasoactive intestinal peptide overexpression mediated by lentivirus attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation

Guo-Ying Sun,Hui-Hui Yang,Xin-Xin Guan,Wen-Jing Zhong,Yong-Ping Liu,Ming-Yuan Du,Xiao-Qin Luo,Yong Zhou,Cha-Xiang Guan

Molecular Immunology（2018）

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摘要

•We firstly found intratracheal injection of Lenti-VIP for 7 days significantly increased intrapulmonary VIP content in mice.•VIP alleviates ALI induced by LPS in vivo.•VIP inhibits pro-inflammatory TNF-α expression in murine macrophages stimulated by LPS via PKC and PKA pathways.

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关键词

Acute lung injury,Vasoactive intestinal peptide,Inflammation,Lentivirus,Macrophages

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