Stress-induced protein S-glutathionylation and phosphorylation crosstalk in cardiac sarcomeric proteins - Impact on heart function

•Cardiac stress activates both oxidative stress and beta-adrenergic pathways.•Cardiac stress regulates specific contractile proteins by phosphorylation and S-glutathionylation modifications.•Intensity/duration of the stress regulates dynamically the pathways to alter differentially cardiac function.