NAMPT-mediated NAD + biosynthesis is indispensable for adipose tissue plasticity and development of obesity.

Karen Nørgaard Nielsen,Julia Peics,Tao Ma,Iuliia Karavaeva,Morten Dall,Sabina Chubanava,Astrid L Basse,Oksana Dmytriyeva,Jonas T Treebak,Zachary Gerhart-Hines

Molecular Metabolism（2018）

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摘要

•Fat-specific Nampt knockout (FANKO) does not alter body composition on chow diet.•NAMPT is essential for adipose expansion and weight gain from high dietary fat.•Loss of adipose NAD+ decreases food intake and improves glucose tolerance.•High fat diet-induced metabolic dysfunction in FANKO mice is reversible.

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关键词

Adipose metabolism,Obesity,NAMPT,NAD+ synthesis,Energy homeostasis,Adipose plasticity,Glucose homeostasis

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