Quercetin attenuates zymosan-induced arthritis in mice.

Carla F S Guazelli,Larissa Staurengo-Ferrari,Ana C Zarpelon,Felipe A Pinho-Ribeiro,Kenji W Ruiz-Miyazawa,Fabiana T M C Vicentini,Josiane A Vignoli,Doumit Camilios-Neto,Sandra R Georgetti,Marcela M Baracat,Rubia Casagrande,Waldiceu A Verri

Biomedicine & Pharmacotherapy（2018）

引用 66|浏览25

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摘要

•Quercetin reduces zymosan-induced articular pain.•Quercetin reduces zymosan-induced cytokine production and NF-κB activation.•Quercetin reduces oxidative stress induced by zymosan.•Quercetin activates Nrf2/HO-1 pathway in experimental arthritis.

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关键词

ARE,COX-2,DTNB,ET-1,GSH,GR,GSH-Px,HO-1,ia,Maf,NADPH,NF-κB,Nrf2,phox,preproET-1,PKC,PG,RA,ROS,VEGF

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