Optimized classification of 18 F-Florbetaben PET scans as positive and negative using an SUVR quantitative approach and comparison to visual assessment.

•SUVR cutoffs to classify Florbetaben PET scans as positive and negative were generated.•SUVR cutoffs were validated against post-mortem histopathological confirmation.•Added value of SUVR cutoff classification to visual assessment was evaluated.•SUVR cutoff classification provided higher accuracy than some non-expert readers.•Results emphasize the contribution that SUVR cutoffs may have to visual assessment.