Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus.
Journal of Autoimmunity(2018)
摘要
•Protein microarray reveals molecular identity of 68 novel SLE autoantigens.•SLE autoantibodies cluster into four biologically functional groups.•SLE autoantigen clusters link to TGF-β/Wnt signalling and TLR signalling/apoptosis regulation.•Novel autoantibodies show selectivity for different SLE manifestations (arthritis, renal, thrombocytopenia).•26-autoantibody panel improves diagnostic accuracy compared to conventional serology.
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关键词
Systemic lupus erythematosus,Autoantibodies,Autoimmunity,Personalised medicine,Diagnostic assay,Protein microarray
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