LncRNA SNHG6 acts as a prognostic factor to regulate cell proliferation in glioma through targeting p21.

•SNHG6 was highly expressed in glioma tissues and cells and predicted poor prognosis for glioma patients.•Silenced SNHG6 inhibited cell proliferation of glioma through affecting cell cycle progression and cell apoptosis.•SNHG6 affected glioma cell proliferation through targeting p21.