Gender Differences in the Recurrence Timing of Patients Undergoing Resection for Non-Small Cell Lung Cancer
Asian Pacific journal of cancer prevention : APJCP(2018)
摘要
Objective: This study was designed to visually represent postoperative recurrence patterns using event dynamics
and to assess sex-based differences in the timing of recurrence for non-small cell lung cancer. Methods: We studied
829 patients (538 men, 291 women) with NSCLC who underwent complete pulmonary resection in 9 hospitals. Event
dynamics with the use of life-table methods were evaluated, and only first events (distant metastases or local recurrence)
were considered. The effects of sex, histological type, pathological stage, and smoking history were studied. Result:
The resulting smoothed hazard rate curves indicated that the recurrence risk pattern definitely correlated with sex, with
a sharp peak in the first year in men and a broad peak during the first 2 to 3 years in women. These findings were also
confirmed by analyses according to pathological stage, histological type, and smoking history. Conclusion: The peak
times of recurrence differed considerably between men and women. The delayed time of peak recurrence in women,
associated with a longer disease-free interval within subsets of patients with similar disease stage, histological type,
and smoking status, might account for the better survival in women.
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关键词
Gender,non-small cell cancer,recurrence,event dynamics
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