Detection of Immunoglobulin G Antibodies to Taenia solium Cysticercosis Antigen Glutathione- S -Transferase-rT24H in Malian Children Using Multiplex Bead Assay.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE(2018)
摘要
Blood samples from 805 students attending 42 elementary schools in Mopti, Sikasso, and Koulikoro regions, and Bamako district in Mali participated in a school water, sanitation, and hygiene intervention. Immunoglobulin (Ig) G responses to several antigens/pathogens were assessed by a multiplex bead assay (MBA), and the recombinant Taenia solium T24H antigen was included. Of all students tested, 8.0% were positive to rT24H, but in some schools 25-30%. A cluster of 12 widespread school locations showed not only a relative risk of 3.23 for T. solium exposure and significantly higher IgG responses (P < 0.001) but also significantly lower elevation (P = 0.04) (m, above sea level) compared with schools outside the cluster. All schools at elevations < 425 m showed significantly higher IgG responses (P = 0.017) than schools at elevations >= 425 m. The MBA is an excellent serological platform that provides cost-effective opportunities to expand testing in serosurveys.
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关键词
antibodies,antigen,glutathione-s-transferase
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