CXCL8 hyper-signaling in the aortic abdominal aneurysm.

•Abdominal Aortic Aneurysmal disease is associated with CXCL8 hyper expression.•The CXCL-8 receptors CXCR1 and -2 are abundantly expression in the aneurysm wall.•Histology for phospho-ERK and PKCΔ/ϕ, and gene expression profiling show exaggerated CXCL8 signaling in abdominal aortic aneurysmal disease.•Interference with CXCL8 signaling through a DF2156, an oral CXCR1/2 antagonist prevented aneurysm formation in the elastase model, an established model for aneurysmal disease.