Structure of the Peptidoglycan Polymerase RodA Resolved by Evolutionary Coupling Analysis

Megan Sjodt,Kelly Brock,Genevieve Dobihal,Patricia D. A. Rohs,Anna G. Green,Thomas A. Hopf,Alexander J. Meeske,Veerasak Srisuknimit,Daniel Kahne,Suzanne Walker,Debora S. Marks,Thomas G. Bernhardt,David Z. Rudner,Andrew C. Kruse

Nature（2018）

引用 124|浏览49

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摘要

Evolutionary coupling-enabled molecular replacement determination of the structure of Thermus thermophilus RodA reveals a highly conserved cavity in its transmembrane domain, and mutagenesis experiments in Bacillus subtilis and Escherichia coli show that perturbation of this cavity abolishes RodA function.

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关键词

Bacteriology,Structural biology,Science,Humanities and Social Sciences,multidisciplinary

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