Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice.

•Peripheral insulin sensitivity and glucose tolerance in aged APP/PS1 mice is comparable to wild-type.•Recognition and spatial memory is impaired in aged wild-type and APP/PS1 mice.•Spatial learning is impaired in aged APP/PS1 mice, compared to age-matched controls.•IRS-1 pSer616 and astrocytes are elevated in brains of aged APP/PS1 mice compared to controls.•IFNγ, IL-1β and IL-4 are elevated in brains of APP/PS1 mice compared to age-matched controls.