Incidence of hypersensitivity and anaphylaxis with sugammadex.

•Sugammadex is indicated for reversal of moderate and deep neuromuscular blockade.•The incidence of hypersensitivity with sugammadex was assessed.•No increase in hypersensitivity was observed with sugammadex vs. placebo/neostigmine.•There were no confirmed cases of anaphylaxis in the pooled studies.•Reports of anaphylaxis during post-marketing use of sugammadex were rare.