Klotho regulates CA1 hippocampal synaptic plasticity.

Qin Li, Hai T Vo,Jing Wang,Stephanie Fox-Quick,Lynn E Dobrunz,Gwendalyn D King

Neuroscience（2017）

引用 27|浏览7

暂无评分

摘要

•Klotho is detected in synaptosomes isolated from hippocampus.•Enhanced CA1 paired-pulse facilitation and long-term potentiation precede cognitive impairment in Klotho-deficient mice.•Klotho overexpression does not affect pre-synaptic plasticity but decreases long-term potentiation at CA1 synapses.

查看译文

关键词

AMPA,EPSC,fEPSP,Hz,I/O,KL,KO,LTP,MAP2,min,MK-801,ml,ms,mV,NMDA,OE,sec,PPF,SMI312,WT

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要