Crocin Reverses Unilateral Renal Ischemia Reperfusion Injury-Induced Augmentation of Oxidative Stress and Toll Like Receptor-4 Activity.

•Crocin protects the kidney against ischemia reperfusion-induced acute kidney injury.•Crocin improves kidney functions post ischemia reperfusion-induced renal injury.•Crocin reduces oxidative stress and enhances antioxidant defenses.•Crocin down-regulated kidney contents of Interleukin-6 and Toll like receptors 4.•Crocin improves kidney histopathology post renal injury.