IFNτ mediates chemotaxis, motility, metabolism and CK18 downregulation in bovine trophoblast cells in vitro via STAT1 and MAPK42/44 signaling.

Placenta（2018）

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摘要

•IFNτ activates MAPK42/44, STAT1, pAKT in bovine F3 trophoblast cells.•IFNτ promotes metabolism, motility, chemotaxis and a depolarisation (CK18).•Autocrine in vitro effects of IFNτ are highly dose-dependent.•Expression of trophoblast CK18 and ezrin also change in vivo (GD 20–39).

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关键词

Interferon tau,Bovine trophoblast,Bovine implantation,Cell culture model

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