Impact of adjuvant hormonotherapy on radiation-induced breast fibrosis according to the individual radiosensitivity: results of a multicenter prospective French trial.

Céline Bourgier,Florence Castan,Olivier Riou, Tan-Dat Nguyen,Karine Peignaux,Claire Lemanski,Jean-Léon Lagrange,Youlia Kirova,Eric Lartigau,Yazid Belkacemi,Sofia Rivera,Georges Noël,Sébastien Clippe,Françoise Mornex,Christophe Hennequin,Sophie Gourgou,Muriel Brengues,Pascal Fenoglietto,Esat Mahmut Ozsahin,David Azria

Oncotarget（2018）

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摘要

Breast Fibrosis-Free Survival (BFFS) rate was assessed relative to RILA categories and to adjuvant HT use (HT and HT, respectively) in a prospective multicentre study (NCT00893035) which enrolled 502 breast cancer patients (456 evaluable patients). Breast fibrosis was recorded according to CTCAE v3.0 grading scale; RILA score was defined according to two categories (<12%: RILA; ≥12%: RILA).

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关键词

breast cancer,hormonotherapy,individual radiosensitivity,late effects,radiotherapy

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