The knockdown of the mediator complex subunit MED30 suppresses the proliferation and migration of renal cell carcinoma cells.

Isabella Syring,Richard Weiten,Tim Müller,Doris Schmidt,Susanne Steiner,Stefan C Müller,Glen Kristiansen,Jörg Ellinger

Annals of Diagnostic Pathology（2018）

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摘要

•Till now, the role of the mediator complex MED30 in urological tumours is unknown.•Altered, mostly overexpressed, MED30 expression leads to a worse outcome in pRCC.•Knockdown of MED30 in ccRCC resulted in a decrease in proliferation, migration, and invasion.

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关键词

Mediator complex subunit MED30,Renal cell carcinoma,Proliferation,Migration

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