Reversible Renal Glomerular Dysfunction in Guinea Pigs Exposed to Glutaraldehyde-Polymerized Cell-Free Hemoglobin.

Xiaoyuan Zhang,Matthew C Williams, Otgonchimeg Rentsendorj,Felice D'Agnillo

Toxicology（2018）

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摘要

•Polymerized hemoglobin induces reversible proteinuria in guinea pigs.•Reversible proteinuria correlates with glomerular podocyte and endothelial changes.•Polymerized hemoglobin induces reversible glomerular glycocalyx damage.•Polymerized hemoglobin and 4-HNE oxidative products accumulated in renal glomeruli.

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关键词

Hb,HbG,GFB,HBOC,RBC,GBM,ROS,WT1,4-HNE,ERG,WGA,SNA,ET,TBST,IgG,BCA,PBST,DAB,DIC,TUNEL,NT,Lb2

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