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Sumoylation regulates the transcriptional activity of different human NFAT isoforms in neurons.

Hanna Vihma,Tõnis Timmusk

Neuroscience Letters（2017）

Cited 9|Views8
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Abstract
•Sumoylation represses the transcriptional activity of Ca2+-regulated NFAT proteins.•Repression of the transcriptional activity of NFAT proteins is cell-type specific.•In cortical neurons, sumoylation represses the transcriptional activity of NFATc1 and NFATc2 isoforms.•In hippocampal neurons, sumoylation represses the transcriptional activity of NFATc1, NFATc2, and NFATc3 isoforms.•Sumoylation represses the transcriptional activity of all NFATs in HEK293-FT cells.
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Key words
NFAT Ca2+-regulated transcription factor,Neuronal activity,Sumoylation,Transactivation,Neurons
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