An aqueous extract of the Anogeissus leiocarpus bark (AEAL) induces the endothelium-dependent relaxation of porcine coronary artery rings involving predominantly nitric oxide.

Lazare Belemnaba,Sylvin Ouédraogo,Mathieu Nitiéma,Thierry Chataigneau,Innocent Pierre Guissou, Valérie B Schini-Kerth,Bernard Bucher,Cyril Auger

Journal of basic and clinical physiology and pharmacology（2018）

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摘要

These findings indicate that AEAL is a potent inducer of endothelium-dependent NO-mediated relaxations in porcine coronary arteries through the redox-sensitive Src/PI3-kinase/Akt pathway-dependent activation of eNOS.

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关键词

Anogeissus leiocarpus,endothelial NO synthase,endothelium-dependent relaxation,nitric oxide

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