Alternative dimerization interfaces in the glucocorticoid receptor-α ligand binding domain.
Biochimica et Biophysica Acta (BBA) - General Subjects(2018)
摘要
•Energetic and sequence conservation analysis of GRα LBD homodimers question the currently accepted dimer architecture.•A more stable and more conserved alternative dimeric assembly than that emphasized in the current literature is proposed.•Comparison with ERα dimer architecture highlights specific features of GRα assembly relevant for signalling.
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关键词
Glucocorticoid receptor,Ligand binding domain,Homodimer,Binding free energy,Sequence conservation,Molecular modeling
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