Natriuretic Peptide Receptor Density and Function Change in Heart Failure - Clinical Implications for Treatment

•Heart failure leads to altered cardiac expression of natriuretic peptides on transcriptional and transcriptional level. •Expression of NPR-A and NPR-B remains unaltered in failing hearts. •Function of NPR-A receptor becomes attenuated in failing hearts, while NPR-B function remains unaltered. •Cardiac expression of NPR-C changes on both transcriptional and translational level patients with heart failure. •Expression of NPR-C in failing hearts varies depending on the etiology of HF.