Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line.
Journal of Molecular and Cellular Cardiology(2018)
摘要
Fibrillation is the most common arrhythmia observed in clinical practice. Understanding of the mechanisms underlying its initiation and maintenance remains incomplete. Functional re-entries are potential drivers of the arrhythmia. Two main concepts are still debated, the “leading circle” and the “spiral wave or rotor” theories. The homogeneous subclone of the HL1 atrial-derived cardiomyocyte cell line, HL1-6, spontaneously exhibits re-entry on a microscopic scale due to its slow conduction velocity and the presence of triggers, making it possible to examine re-entry at the cellular level.
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关键词
Re-entry,Rotational activity,Triggers,HL1-6 myocytes,Monolayer culture,Optical mapping
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