Mutations affecting the actin regulator WDR1 lead to aberrant lymphoid immunity.

Laurène Pfajfer,Nina K Mair,Raúl Jiménez-Heredia,Ferah Genel,Nesrin Gulez, Ömür Ardeniz,Birgit Hoeger,Sevgi Köstel Bal,Christoph Madritsch,Artem Kalinichenko,Rico Chandra Ardy, Bengü Gerçeker,Javier Rey-Barroso,Hanna Ijspeert,Stuart G Tangye,Ingrid Simonitsch-Klupp,Johannes B Huppa,Mirjam van der Burg,Loïc Dupré,Kaan Boztug

Journal of Allergy and Clinical Immunology（2018）

引用 62|浏览38

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摘要

Our study identifies a novel role for WDR1 in adaptive immunity, highlighting WDR1 as a central regulator of actin turnover during the formation of the B-cell and T-cell immunological synapses.

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关键词

WD repeat–containing protein 1,actin cytoskeleton,immunodeficiency,lymphocytes,immunologic synapse

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