Structure-activity relationships of rationally designed AMACR 1A inhibitors.

Maksims Yevglevskis,Guat L Lee,Amit Nathubhai,Yoana D Petrova,Tony D James,Michael D Threadgill,Timothy J Woodman,Matthew D Lloyd

Bioorganic Chemistry（2018）

引用 6|浏览20

暂无评分

摘要

•Structure-activity relationships of rationally designed AMACR inhibitors.•Quantification of effects of changing aromatic and aliphatic side-chain.•Quantification of effects of changing (2-methyl)acyl-CoA core.•Prediction of potency using lipophilicity and rationalisation of properties.•Validation of colorimetric assay for testing inhibitor properties.

查看译文

关键词

α-Methylacyl-CoA racemase (AMACR, P504S),Drug lipophilicity,Enzyme inhibitors,Rational drug design,Structure-activity relationships

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要