Genetic Polymorphism of Thymic Stromal Lymphopoietin in Korean Patients with Atopic Dermatitis and Allergic March.

Thymic stromal lymphopoietin(TSLP) is recognized as key cytokine in T helper type 2 (Th 2) cell differentiation and contributes to the pathogenesis of atopic disease. The TSLP gene on chromosome 5q22.1 and atopic cytokine gene on 5q31 are adjacent to each other. Based on their genetic location, it is suggested that the TSLP gene is involved in the progression or activity of atopic disease. Genetic association studies involving TSLP single nucleotide polymorphisms (SNPs) and allergic rhinitis or asthma in different racial group have yielded disparate and inconsistent results. This article is protected by copyright. All rights reserved.